In this episode of Fireside Chat, we learn more about the Yale Cultural Ambassador Program and its success in accelerating minority participation in the Yale School of Medicine’s clinical research. The background, of course, is that minority participation in clinical trials is a long-standing, national challenge. Minority communities are distrustful of clinical research due, in part, through misguided past research trials such as the Tuskegee Syphilis Study. Further, communication with minority communities about science and research has been sparse and not generally creative or thoughtful. The Yale Cultural Ambassador Program was designed to increase minority participation in clinical trials, which it has accomplished beyond expectations. Furthermore, it has bridged the minority and scientific communities and there are open lines of communication about COVID, vaccines, and youth exposure to science and medicine.